BP802TSemester 82 creditsTheory

Clinical Pharmacotherapeutics

Complete unit-wise syllabus for BP802T as per the PCI B.Pharm NEP 2020 curriculum (Semester 8 — AI Ethics + Clinical + Final Research).

URL:https://pharmacode.in/syllabus/semester-8/bp802t-clinical-pharmacotherapeutics/

Unit-wise Syllabus

5 Units

Drug Therapy in Special Populations6 Hours

Paediatric pharmacotherapy: pharmacokinetic differences (absorption, distribution, metabolism, excretion); dosing methods (mg/kg, BSA, age-based rules — Young's, Clark's); off-label drug use; paediatric formulation challenges
Geriatric pharmacotherapy: age-related PK/PD changes; polypharmacy assessment; Beers criteria; START/STOPP criteria; fall risk medications; dose adjustment in elderly
Drug therapy in pregnancy and lactation: teratogen classification; risk-benefit assessment; drugs safe in pregnancy; breastfeeding safety (LactMed, Hale's Lactation Risk Categories)

Pharmacotherapy of Cardiovascular Diseases6 Hours

Heart failure: pathophysiology; ACE inhibitors/ARBs, beta-blockers, aldosterone antagonists, diuretics, sacubitril/valsartan (ARNI) — evidence-based pharmacotherapy; pharmacist monitoring parameters
Acute Coronary Syndrome (ACS): antiplatelet therapy (aspirin, clopidogrel, ticagrelor), anticoagulants, fibrinolytics, GP IIb/IIIa inhibitors; STEMI vs. NSTEMI management
Dyslipidaemia: statin therapy (intensity-based dosing), ezetimibe, PCSK9 inhibitors, fibrates; cardiovascular risk calculators; monitoring and target LDL levels

Pharmacotherapy of Endocrine and Metabolic Disorders6 Hours

Diabetes mellitus management: insulin regimens (basal-bolus, premixed); ADA/IDF glycaemic targets; algorithm-based selection of oral/injectable antidiabetics; hypoglycaemia management; sick-day rules
Thyroid disorders: levothyroxine dosing and monitoring in hypothyroidism; antithyroid drug management of hyperthyroidism; thyroid crisis/myxoedema coma — emergency management
Obesity pharmacotherapy: orlistat, GLP-1 agonists (semaglutide, liraglutide) in obesity; bariatric surgery and pharmacokinetic changes; metabolic syndrome management

Pharmacotherapy of Infectious Diseases6 Hours

Sepsis and septic shock: Surviving Sepsis Campaign guidelines; antibiotic choice and de-escalation; pharmacokinetic/pharmacodynamic (PK/PD) optimisation of antibiotics in ICU (AUC/MIC, T>MIC, Cmax/MIC targets)
Tuberculosis: RNTCP/NTEP treatment regimens (DOTS-Plus); anti-TB drug monitoring; management of MDR-TB and XDR-TB; pharmacovigilance of anti-TB drugs
HIV pharmacotherapy: WHO preferred first-line ART regimens; adherence strategies; opportunistic infection prophylaxis; drug-drug interactions with ART

Dosing in Renal and Hepatic Impairment6 Hours

Renal impairment: creatinine clearance calculation (Cockcroft-Gault); drug dose adjustment using GFR (Aronoff guidelines); drugs to avoid in renal failure; haemodialysis supplemental dosing
Hepatic impairment: Child-Pugh and MELD scoring; impact on drug metabolism (CYP3A4 reduction, glucuronidation) and protein binding; dose reduction strategies; drugs contraindicated in liver disease
Drug interactions in clinical practice: clinically significant PK and PD interactions; interaction severity classification; pharmacist interventions; use of drug interaction databases (Lexicomp, Micromedex, Medscape)

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