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BP402TSemester 43 creditsTheory

Medicinal Chemistry

Complete unit-wise syllabus for BP402T as per the PCI B.Pharm NEP 2020 curriculum (Semester 4 — Medicinal Chemistry + 1st Internship).

All Sem 4 Subjects
URL:https://pharmacode.in/syllabus/semester-4/bp402t-medicinal-chemistry/

Unit-wise Syllabus

5 Units
1
Drug-Receptor Interactions and SAR Fundamentals9 Hours
  • Drug-receptor interactions: forces involved (covalent, ionic, hydrogen bonds, van der Waals, hydrophobic interactions); pharmacophore concept
  • Structure-Activity Relationship (SAR): electronic effects, steric effects, lipophilicity; bioisosterism; prodrug design; soft drugs
  • Drug metabolism and bioavailability: metabolic soft spots; prodrug strategies to improve bioavailability; ADMET properties in drug design
2
Analgesics, NSAIDs, and Cardiovascular Drugs9 Hours
  • Analgesics: opioid analgesics — morphine, codeine, pethidine, methadone — structural features, SAR, mechanism
  • NSAIDs: salicylates (aspirin, diflunisal), para-aminophenol derivatives (paracetamol), pyrazolone derivatives, propionic acid derivatives (ibuprofen, naproxen), oxicam derivatives (piroxicam), COX-2 inhibitors (celecoxib) — SAR
  • Cardiovascular drugs: antihypertensives (ACE inhibitors, ARBs, calcium channel blockers, beta-blockers), antiarrhythmics, antithrombotics — structural features and SAR
3
Antibacterial and Antifungal Agents9 Hours
  • Sulfonamides: structure, SAR, mechanism; trimethoprim; cotrimoxazole
  • Fluoroquinolones: nalidixic acid, norfloxacin, ciprofloxacin, levofloxacin — SAR, mechanism of action
  • Beta-lactam antibiotics: penicillins — structure, SAR, mechanism, resistance; cephalosporins — generations and SAR; aminoglycosides, tetracyclines, macrolides
  • Antifungal agents: azoles (fluconazole, itraconazole) — mechanism and SAR; amphotericin B structure; echinocandins
4
CNS Drugs — Sedatives, Hypnotics and Antipsychotics9 Hours
  • Sedative-hypnotics: benzodiazepines — diazepam, lorazepam, alprazolam; SAR; mechanism at GABA-A receptor; non-benzodiazepines (zolpidem)
  • Barbiturates: structure, SAR, mechanism; classification by duration; clinical applications and limitations
  • Antipsychotics: phenothiazines (chlorpromazine, trifluoperazine) — SAR, dopamine receptor blockade; butyrophenones (haloperidol); atypical antipsychotics (clozapine, risperidone)
5
Antidepressants, Antiepileptics and Antivirals9 Hours
  • Antidepressants: TCAs (imipramine, amitriptyline) — SAR; SSRIs (fluoxetine, sertraline) — SAR; MAOIs — mechanism and examples
  • Antiepileptics: hydantoins (phenytoin), barbiturates (phenobarbitone), succinimides (ethosuximide), valproic acid, carbamazepine, benzodiazepines — SAR and mechanism
  • Antivirals: nucleoside analogues (acyclovir, zidovudine, lamivudine) — mechanism and SAR; protease inhibitors; neuraminidase inhibitors (oseltamivir); HIV drug classes and combination therapy

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  • Reference textbooks and recommended reading list
  • Previous year question papers (PYQ)
  • Topic-wise short notes and revision summaries
  • Suggested external resources and video tutorials

Other subjects in Semester 4

BP401THerbal Drug TechnologyBP403TPharmaceutical BiotechnologyBP404TSocial Pharmacy and Public HealthBP405TSystemic Pharmacology IBP406PHerbal Drug Technology (Practical)BP407PMedicinal Chemistry (Practical)BP408PPharmaceutical Biotechnology (Practical)BP409PSocial Pharmacy and Public Health (Practical)BP410PSystemic Pharmacology I (Practical)BP411IInternship I (Mandatory)
BP401TBP403T